PPARGC1A

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Gene Information

Gene Symbol
PPARGC1A
Aliases
PGC1, PGC1A, PGC-1alpha, PPARAGCIα, PPARGC1
HGNC ID
HGNC:9237
NCBI Gene ID
10891
Ensembl Gene ID
ENSG00000109819
Gene Type
protein coding

Genomic Location

Chromosome
4
Assembly
GRCh38
Start Position
23,755,041
End Position
23,904,089
Number of Exons
13
Gene Length
149,049 bp

Overview

PPARGC1A is a transcriptional coactivator that regulates and interacts with genes involved in energy metabolism. It has a role in regulating metabolism, inflammation, oxidative stress resistance and mitochondrial biogenesis and function. SIRT1 has been reported to be a functional regulator of PPARGC1A. In mice, knockout of PPARGC1A accelerates vascular aging and atherosclerosis, coinciding with telomere dysfunction and shortening and DNA damage. Expression of PPARGC1A coactivates TERT transcription and reverses telomere malfunction. In humans, PPARGC1A has been associated with cholesterol and obesity as well as age-related diseases like type 2 diabetes. Thus, PPARGC1A may play a role in in ameliorating senescence, aging, and age-associated chronic diseases.

Research Papers

6 papers in databaseSearch for More Papers
#1
Score:
80%

Telomere dysfunction induces metabolic and mitochondrial compromise.

Nature
2011
PMID: 21307849

Modification Effects

Telomere dysfunction; p53-mediated repression of PGC-1alpha and PGC-1beta promoters; impaired mitochondrial biogenesis and function

Longevity Association

Organ and metabolic failure; diminished organismal fitness in mice with telomere dysfunction; mechanism: telomere-p53-PGC axis disruption, increased reactive oxygen species, and impaired mitochondrial function

#2
Score:
80%

Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function.

Autophagy
2022
PMID: 35104184

Modification Effects

ULK1 or ULK2 loss; enhanced basal autophagy in perinatal cardiomyocytes, impaired autophagy in adult cardiomyocytes

Longevity Association

Reduced survival in cU1/2-DKO mice; age-related cardiomyopathy, early death in icU1-KO mice; mechanism: impaired autophagy, mitochondrial dysfunction

#3
Score:
80%

Exome sequencing of three cases of familial exceptional longevity.

Aging Cell
2014
PMID: 25116423

Longevity Association

Exceptional longevity in humans; candidate genes include APOB, PPARGC1A, NRG1, RAD52, RAD51, NCOR1, and ADCY5

#4
Score:
80%

Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to Insulin Resistance and Obesity in Hypercholesterolemic Mice.

Cells
2024
PMID: 38891115

Modification Effects

Deletion of murine ortholog of human 9p21.3 locus; decreased mRNA expression of insulin receptors and downregulation of Sirt1-Ppargc1a-Ucp2 pathway in white adipose tissue

#5
Score:
70%

Responses to Maximal Strength Training in Different Age and Gender Groups.

Front Physiol
2021
PMID: 33679448

Modification Effects

PPARGC1A Gly482Ser (rs8192678) polymorphism; T allele carriers had 15% higher baseline 1RM, C allele carriers improved 1RM by 34.2% more than TT homozygotes

#6
Score:
60%

Genetic variation in healthy oldest-old.

PLoS One
2009
PMID: 19680556

Longevity Association

Prolonged lifespan in healthy oldest-old humans; mechanism: possibly enhanced disease resistance and lack of disease susceptibility factors

Return to Knowledge Base