HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Gene Information

Gene Symbol

HIF1A

Aliases

MOP1, HIF-1alpha, PASD8, HIF1, bHLHe78

HGNC ID

HGNC:4910

NCBI Gene ID

3091

Ensembl Gene ID

ENSG00000100644

Gene Type

protein coding

Genomic Location

Chromosome

Assembly

GRCh38

Start Position

61,695,456

End Position

61,748,263

Number of Exons

Gene Length

52,808 bp

Overview

HIF1A is a transcription factor that responds to oxidative stress and oxygen. Changes in HIF1A with age have been reported in rats and could be related to age-related pathologies, such as neurodegeneration. Deficiencies in HIF1A have not been associated with ageing in mice. Further evidence is needed to directly link HIF1A to human ageing.

Research Papers

1 paper in databaseSearch for More Papers

Score:

80%

Genetic modification increases the survival and the neuroregenerative properties of transplanted neural stem cells.

JCI Insight

2020

PMID: 31999645

Modification Effects

Genetic modification of hNSCs to express Hif1a, Akt1, Bcl-2, or Bcl-xl; increased cell survival and enhanced exit from cell cycle

Longevity Association

Improved survival of transplanted hNSCs; enhanced neuroregeneration and behavioral recovery in mice with stroke; mechanism: reduced cell death and enhanced differentiation

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