CAT

catalase

Gene Information

Gene Symbol
CAT
HGNC ID
HGNC:1516
NCBI Gene ID
847
Ensembl Gene ID
ENSG00000121691
Gene Type
protein coding

Genomic Location

Chromosome
11
Assembly
GRCh38
Start Position
34,438,906
End Position
34,472,061
Number of Exons
13
Gene Length
33,156 bp

Overview

Catalase is an antioxidant that protects cells from hydrogen peroxide. Some experiments in invertebrates suggest a role for CAT in ageing. Overexpression of CAT and SOD1 in short-lived strains of fruit flies extends lifespan and appears to delay ageing, but the same effects are not witnessed in long-lived strains. CAT overexpression targeted to mitochondria extends longevity in mice, but this appears to be related to a lower incidence of cardiac pathology rather than delayed ageing. These mutants are also more resistant to age-related skeletal muscle dysfunction and exhibit improved voluntary exercise, increased muscle force, decreased intracellular Ca(2+) leak and increased sarcoplasmic reticulum Ca(2+) load. Cardiac-specific overexpression prolongs lifespan in mice. Although it has been argued that CAT plays a role in ageing, there is no direct evidence linking CAT to human ageing.

Research Papers

12 papers in databaseSearch for More Papers
#1
Score:
90%

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer.

Nucleic Acids Res
2018
PMID: 29733381

Modification Effects

rs2802292 G-allele creates HSE binding site for HSF1; increased FOXO3 expression through enhancer function in intron 2

Longevity Association

Longevity association in humans; rs2802292 G-allele correlated with reduced age-related diseases and increased survival in centenarians; mechanism: enhanced stress response, ROS detoxification, and DNA repair through HSF1-FOXO3 axis

#2
Score:
80%

Effects of Aging and Oxidative Stress on Spermatozoa of Superoxide-Dismutase 1- and Catalase-Null Mice.

Biol Reprod
2016
PMID: 27465136

Modification Effects

SOD1-null and Catalase-null mutations; altered antioxidant properties and increased susceptibility to redox dysfunction

Longevity Association

Reduced fertility and increased DNA damage in aged Sod(-/-) mice; mechanism: oxidative stress and redox dysfunction

#3
Score:
80%

Analysis of antioxidative factors related to AMD risk development in the polish patients.

Acta Ophthalmol
2017
PMID: 27935234

Modification Effects

GPx Pro197Leu polymorphism; reduced antioxidant enzyme activity, SOD1 +35A/C polymorphism; altered SOD activity

Longevity Association

Increased risk of age-related macular degeneration; mechanism: insufficient antioxidant capacity, oxidative stress

#4
Score:
80%

Phospholipid Phosphatase 3 (PLPP3) Induces Oxidative Stress to Accelerate Ovarian Aging in Pigs.

Cells
2024
PMID: 39272993

Modification Effects

PLPP3 upregulation; decreased SIRT1 and SIRT6 expressions, inhibited SOD1, CAT, FSP1, FTH1, and SLC7A11 expressions, and induced autophagy

Longevity Association

Accelerated ovarian aging in pigs; mechanism: increased oxidative stress, autophagy, and cellular senescence

#5
Score:
80%

Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging.

ACS Chem Biol
2020
PMID: 32589395

Modification Effects

MAO A variants at Lys305 (K305Q, K305M, K305S); altered enzymatic activity and ROS production

Longevity Association

Decreased ROS levels and senescence markers in cardiomyoblasts; potential attenuation of cardiomyocytes aging

#6
Score:
80%

Onion Vinegar Quality Evaluation and its Alleviate Oxidative Stress Mechanism in Caenorhabditis elegans Via SKN-1.

Plant Foods Hum Nutr
2022
PMID: 35441311

Modification Effects

SKN-1 modulation; enhanced transcription factor activity

Longevity Association

Maximum lifespan extension to 26 days in C. elegans; mechanism: SKN-1 signaling pathway activation, reduced oxidative stress

#7
Score:
80%

Aging Model for Analyzing Drug-Induced Proarrhythmia Risks Using Cardiomyocytes Differentiated from Progeria-Patient-Derived Induced Pluripotent Stem Cells.

Int J Mol Sci
2023
PMID: 37569335

Longevity Association

Increased proarrhythmia sensitivity in progeria cardiomyocytes; potential model for aging-related cardiac safety concerns

#8
Score:
80%

Mutation Types of CYP71P1 Cause Different Phenotypes of Mosaic Spot Lesion and Premature Leaf Senescence in Rice.

Front Plant Sci
2021
PMID: 33833770

Modification Effects

CYP71P1 mutations (SNP-caused single amino acid change and early termination of translation); altered regulation of cell death and senescence

Longevity Association

Premature leaf senescence in rice; mechanism: accumulation of hydrogen peroxide, decreased SOD and CAT activities, and down-regulated chloroplast synthesis/photosynthesis genes

#9
Score:
80%

GPX1 knockout, not catalase knockout, causes accelerated abnormal optical aberrations and cataract in the aging lens.

Mol Vis
2022
PMID: 35400989

Modification Effects

GPX1 knockout; increased oxidative stress, altered lens transparency and optical quality

Longevity Association

Accelerated cataract formation in aging GPX1(-/-) mice; mechanism: increased oxidative stress, altered gap junction coupling resistance

#10
Score:
80%

Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging.

Behav Brain Res
2017
PMID: 28457881

Modification Effects

SOD2 polymorphism (rs4880); altered antioxidant enzyme activity

Longevity Association

Suboptimal brain aging in humans with SOD2 CC genotype; increased radial diffusivity in white matter and potential cognitive decline

#11
Score:
80%

Targeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation.

PLoS One
2015
PMID: 25811370

Modification Effects

Lgr4 gene deletion; decreased expression of antioxidant enzymes (catalase and superoxidase dismutase-1), altered protein expression

Longevity Association

Premature cataract formation, increased sensitivity to oxidative stress; mechanism: decreased antioxidant defense in lens epithelial cells of mice

#12
Score:
60%

Genetical Signature-An Example of a Personalized Skin Aging Investigation with Possible Implementation in Clinical Practice.

J Pers Med
2023
PMID: 37763073
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